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Nephrology Dialysis Transplantation (2010) Abstract of paper published online in April 12, 2010
A novel bioactive hemodialysis system using dissolved dihydrogen(H<sub>2</sub>) produced by water electrolysis: A clinical trial
Background/purpose:Chronic inflammation in hemodialysis (HD) patients is a risk for poor prognosis. However, therapeutic approaches are limited. It is shown that Hydrogen gas (H2) has been shown to ameliorate oxidative and inflammatory injuries to organs in animal models. We thus developed a HD system using dialysis solution with high levels of dissolved H2, and examined the clinical effects.

Subjects/method:Dialysis solution with H2 (60 ppb in average) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H2 generated by the water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at 3 sessions a week.

Results:During the study period, no adverse clinical signs or symptoms were observed. A significant fall in systolic blood pressure (SBP) before and after dialysis sessions was seen during the study, and a substantial number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; p<0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (p<0.01) and myeloperoxidase (p<0.05) were identified.

Conclusion:Including H2 in HD solution ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for uremia control as a maintenance modality.
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